Publications

Featured Publications

Garcia-Bermudez J, La K, Baudrier L, Papagiannkopoulos T, Snuderl M, Lewis C, Possemato R and Birsoy K*. Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors. Nature Cell Biology. 2018 (accepted) *corresponding


1: Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy

VO, Papagiannakopoulos T, Sabatini DM, Birsoy K*, Possemato R*. Serine Catabolism

by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and

Maintenance of Formylmethionyl-tRNAs. Mol Cell. 2018 Feb 15;69(4):610-621.e5.

doi: 10.1016/j.molcel.2018.01.024. PubMed PMID: 29452640; PubMed Central PMCID:

PMC5819360. *co-corresponding

 

2: Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams

S, Sabatini DM*, Birsoy K*, Possemato R*. NFS1 undergoes positive selection in lung

tumours and protects cells from ferroptosis. Nature. 2017 Nov

30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22. PubMed PMID:

29168506; PubMed Central PMCID: PMC5808442. *co-corresponding

 

3: Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM,

Chandel NS. A CRISPR screen identifies a pathway required for paraquat-induced

cell death. Nat Chem Biol. 2017 Dec;13(12):1274-1279. doi: 10.1038/nchembio.2499.

Epub 2017 Oct 23. PubMed PMID: 29058724; PubMed Central PMCID: PMC5698099.

 

4: Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo

JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM,

Vazquez F, Widlund HR, Sabatini DM, Hahn WC. PIK3CA mutant tumors depend on

oxoglutarate dehydrogenase. Proc Natl Acad Sci U S A. 2017 Apr

25;114(17):E3434-E3443. doi: 10.1073/pnas.1617922114. Epub 2017 Apr 10. PubMed

PMID: 28396387; PubMed Central PMCID: PMC5410781.

 

5: Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp

KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É,

Marsolais D, Bossé Y, Birsoy K, Laplante M. Amplification of Adipogenic

Commitment by VSTM2A. Cell Rep. 2017 Jan 3;18(1):93-106. doi:

10.1016/j.celrep.2016.12.015. PubMed PMID: 28052263; PubMed Central PMCID:

PMC5551894.

 

6: Garcia-Bermudez J, Birsoy K. Drugging ACAT1 for Cancer Therapy. Mol Cell. 2016

Dec 1;64(5):856-857. doi: 10.1016/j.molcel.2016.11.023. PubMed PMID: 27912096.

 

7: Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM. Absolute Quantification

of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell.

2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040. PubMed PMID:

27565352; PubMed Central PMCID: PMC5030821.

 

8: Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R,

Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD,

Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A,

Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and

one-carbon unit fate. Nat Chem Biol. 2016 Jul 19;12(8):656. doi:

10.1038/nchembio0816-656. PubMed PMID: 27434767.

 

9: Chidley C, Trauger SA, Birsoy K, O'Shea EK. The anticancer natural product

ophiobolin A induces cytotoxicity by covalent modification of

phosphatidylethanolamine. Elife. 2016 Jul 12;5. pii: e14601. doi:

10.7554/eLife.14601. PubMed PMID: 27403889; PubMed Central PMCID: PMC4942256.

 

10: Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R,

Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M,

Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X,

Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB,

Sabatini DM. A PHGDH inhibitor reveals coordination of serine synthesis and

one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi:

10.1038/nchembio.2070. Epub 2016 Apr 25. Erratum in: Nat Chem Biol. 2016 Jul

19;12 (8):656. PubMed PMID: 27110680; PubMed Central PMCID: PMC4871733.

 

11: Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini

DM. Identification and characterization of essential genes in the human genome.

Science. 2015 Nov 27;350(6264):1096-101. doi: 10.1126/science.aac7041. Epub 2015

Oct 15. PubMed PMID: 26472758; PubMed Central PMCID: PMC4662922.

 

12: Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to

"Nuclear Factor-Y is an adipogenic factor that regulates leptin gene

expression"[Mol Metab 4 (2015) 392-405]. Mol Metab. 2015 Jun 6;4(8):592. doi:

10.1016/j.molmet.2015.05.004. eCollection 2015 Aug. PubMed PMID: 26266092; PubMed

Central PMCID: PMC4529494.

 

13: Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An

Essential Role of the Mitochondrial Electron Transport Chain in Cell

Proliferation Is to Enable Aspartate Synthesis. Cell. 2015 Jul 30;162(3):540-51.

doi: 10.1016/j.cell.2015.07.016. PubMed PMID: 26232224; PubMed Central PMCID:

PMC4522279.

 

14: Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Nuclear Factor-Y

is an adipogenic factor that regulates leptin gene expression. Mol Metab. 2015

Feb 13;4(5):392-405. doi: 10.1016/j.molmet.2015.02.002. eCollection 2015 May.

Erratum in: Mol Metab. 2015 Aug;4(8):592. PubMed PMID: 25973387; PubMed Central

PMCID: PMC4420997.

 

15: Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y,

Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon

KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. SHMT2 drives glioma cell

survival in ischaemia but imposes a dependence on glycine clearance. Nature. 2015

Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. PubMed PMID:

25855294; PubMed Central PMCID: PMC4533874.

 

16: Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for

mTORC1 in erythropoiesis and anemia. Elife. 2014 Sep 8;3:e01913. doi:

10.7554/eLife.01913. PubMed PMID: 25201874; PubMed Central PMCID: PMC4179304.

 

 

17: Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar

EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM. Inhibition of

ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in

mammalian cells. Cell Rep. 2014 Apr 10;7(1):27-34. doi:

10.1016/j.celrep.2014.02.046. Epub 2014 Mar 27. PubMed PMID: 24685140; PubMed

Central PMCID: PMC4040975.

 

18: Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T,

Chen WW, Clish CB, Sabatini DM. Metabolic determinants of cancer cell sensitivity

to glucose limitation and biguanides. Nature. 2014 Apr 3;508(7494):108-12. doi:

10.1038/nature13110. Epub 2014 Mar 16. PubMed PMID: 24670634; PubMed Central

PMCID: PMC4012432.

 

19: Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck

AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are

hyperactivating and can predict rapamycin sensitivity. Cancer Discov. 2014

May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. PubMed

PMID: 24631838; PubMed Central PMCID: PMC4012430.

 

 

20: Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu

H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The

adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Sci Signal.

2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal.

2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W]. PubMed

PMID: 24550542; PubMed Central PMCID: PMC4260967.

 

 

21: Birsoy K, Festuccia WT, Laplante M. A comparative perspective on lipid

storage in animals. J Cell Sci. 2013 Apr 1;126(Pt 7):1541-52. doi:

10.1242/jcs.104992. PubMed PMID: 23658371.

 

 

22: Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW,

Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM.

MCT1-mediated transport of a toxic molecule is an effective strategy for

targeting glycolytic tumors. Nat Genet. 2013 Jan;45(1):104-8. doi:

10.1038/ng.2471. Epub 2012 Dec 2. PubMed PMID: 23202129; PubMed Central PMCID:

PMC3530647.

 

 

23: Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A,

Ekstrand MI, Friedman JM. Molecular profiling of activated neurons by

phosphorylated ribosome capture. Cell. 2012 Nov 21;151(5):1126-37. doi:

10.1016/j.cell.2012.10.039. PubMed PMID: 23178128; PubMed Central PMCID:

PMC3839252.

 

 

24: Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini

DM. DEPTOR cell-autonomously promotes adipogenesis, and its expression is

associated with obesity. Cell Metab. 2012 Aug 8;16(2):202-12. doi:

10.1016/j.cmet.2012.07.008. PubMed PMID: 22883231; PubMed Central PMCID:

PMC3463374.

 

 

25: Birsoy K, Sabatini DM, Possemato R. Untuning the tumor metabolic machine:

Targeting cancer metabolism: a bedside lesson. Nat Med. 2012 Jul 6;18(7):1022-3.

doi: 10.1038/nm.2870. PubMed PMID: 22772555.

 

 

26: Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S,

Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg

LR, Bhan AK, Deshpande V, Sabatini DM. mTORC1 in the Paneth cell niche couples

intestinal stem-cell function to calorie intake. Nature. 2012 Jun

28;486(7404):490-5. doi: 10.1038/nature11163. PubMed PMID: 22722868; PubMed

Central PMCID: PMC3387287.

 

 

27: Ceyhan O, Birsoy K, Hoffman CS. Identification of biologically active

PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol.

2012 Jan 27;19(1):155-63. doi: 10.1016/j.chembiol.2011.12.010. PubMed PMID:

22284362.

 

 

28: Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS.

Analysis of gene networks in white adipose tissue development reveals a role for

ETS2 in adipogenesis. Development. 2011 Nov;138(21):4709-19. doi:

10.1242/dev.067710. PubMed PMID: 21989915; PubMed Central PMCID: PMC3190384.

 

 

29: Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S,

Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS,

Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE,

Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Functional genomics

reveal that the serine synthesis pathway is essential in breast cancer. Nature.

2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350. PubMed PMID: 21760589;

PubMed Central PMCID: PMC3353325.

 

 

30: Chen W, Zhang X, Birsoy K, Roeder RG. A muscle-specific knockout implicates

nuclear receptor coactivator MED1 in the regulation of glucose and energy

metabolism. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10196-201. doi:

10.1073/pnas.1005626107. Epub 2010 May 17. PubMed PMID: 20479251; PubMed Central

PMCID: PMC2890439.

 

 

31: Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman

JM. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab. 2010

Jan;11(1):11-22. doi: 10.1016/j.cmet.2009.11.007. Erratum in: Cell Metab. 2010

Mar 3;11(3):239. PubMed PMID: 20074524.

 

 

32: Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte

progenitor cells in vivo. Cell. 2008 Oct 17;135(2):240-9. doi:

10.1016/j.cell.2008.09.036. Epub 2008 Oct 2. PubMed PMID: 18835024.

 

 

33: Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P,

Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling

the recovery of adipose tissue mass: An in vivo imaging approach. Proc Natl Acad

Sci U S A. 2008 Sep 2;105(35):12985-90. doi: 10.1073/pnas.0805621105. Epub 2008

Aug 27. PubMed PMID: 18753616; PubMed Central PMCID: PMC2526100.

 

 

34: Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by

KLF4. Cell Metab. 2008 Apr;7(4):339-47. doi: 10.1016/j.cmet.2008.02.001. PubMed

PMID: 18396140; PubMed Central PMCID: PMC2430156.

 

 

35: Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay

RT, Oelgeschläger T. SUMO-1 modification of human transcription factor (TF) IID

complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1

modification of hsTAF5. J Biol Chem. 2005 Mar 18;280(11):9937-45. Epub 2005 Jan

6. PubMed PMID: 15637059.