For several years, a class of anti-diabetic drugs known as biguanides, has been associated with anti-cancer properties. A number of retrospective studies have shown that the widely used diabetes drug metformin can benefit some cancer patients. Despite this intriguing correlation, it has been unclear how metformin might exert its anti-cancer effects. Continue reading
Metabolite transporters are upregulated in subsets of cancers, and it therefore may be possible to develop toxic molecules that exploit these transporters to selectively enter and target cancer cells. Here we found one example using a haploid based genetic screen against a tool compound, 3-BrPA. Continue reading
