Publications

Publications

1. Khan, A., Yen, F.S., Unlu G., DelGaudio, N., Wangdu, K., Cho, K., Gamazon, E., Patti, G.J., and Birsoy, K.*. Machine learning guided discovery of SLC25A45 as mediator of mitochondrial methylated amino acid import and carnitine synthesis. Cell Metabolism; 2025 (in press).
2. Yeh H.W., DelGaudio N.L., Uygur B., Millet A., Khan A., Unlu G., Xiao M., Timson R.C., Li C., Ozcan K., Smith K.W., Nascentes Melo L.M., Allies G., Basturk O., Sickmann A., Bayraktar E.C., Possemato R., Tasdogan A., and Birsoy, K.*. Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling. Cancer Discovery 2025 Jul 31; doi:10.1158/2159-8290.

1. Soula M., Unlu G., Welch R., Chudnovskiy A., Uygur B., Shah V., Alwaseem H., Bunk P., Subramanyam V., Yeh H.W., Khan A., Heissel S., Goodarzi H., Victora G.D., Beyaz S., Birsoy K.*. Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer. Nature. England; 2024 Aug 7; PMID: 39112706.
2. Khan A., Unlu G., Lin P., Liu Y., Kilic E., Kenny T.C., Birsoy K.*, Gamazon E.R.*. Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import. Nature Genetics. United States; 2024 Aug; 56(8):1614–1623. PMID: 38977856.

1. Liu Y., Liu S., Tomar A., Yen F.S., Unlu G., Ropek N., Weber R.A., Wang Y., Khan A., Gad M., Peng J., Terzi E., Alwaseem H., Pagano A.E., Heissel S., Molina H., Allwein B., Kenny T.C., Possemato R.L., Zhao L., Hite R.K., Vinogradova E.V., Mansy S.S., Birsoy K.*. Autoregulatory control of mitochondrial glutathione homeostasis. Science. United States; 2023 Nov 17; 382(6672): 820–828. PMCID: PMC11170550.
2. Kenny T.C., Khan A., Son Y., Yue L., Heissel S., Sharma A., Pasolli H.A., Liu Y., Gamazon E.R., Alwaseem H., Hite R.K., Birsoy K.*. Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Cell Metabolism. 2023 Jun 6; 35(6): 1057–1071.e12. PMCID: PMC10367582.

1. Unlu G., Prizer B., Erdal R., Yeh H.W., Bayraktar E.C., Birsoy K.*. Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Molecular Cell. 2022 Aug 4; 82(15): 2832–2843.e7. PMCID: PMC9356996.
2. Garcia-Bermudez J., Badgley M.A., Prasad S., Baudrier L., Liu Y., La K., Soula M., Williams R.T., Yamaguchi N., Hwang R.F., Taylor L.J., de Stanchina E., Rostandy B., Alwaseem H., Molina H., Bar-Sagi D., Birsoy K.*. Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia. Nature Metabolism. Germany; 2022 Jun; 4(6): 724–738. PMCID: PMC9678334.

1. Wang Y., Yen F.S., Zhu X.G., Timson R.C., Weber R., Xing C., Liu Y., Allwein B., Luo H., Yeh H.W., Heissel S., Unlu G., Gamazon E.R., Kharas M.G., Hite R., Birsoy K.*. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature. 2021 Nov; 599(7883): 136–140.
2. Zhu X.G., Chudnovskiy A., Baudrier L., Prizer B., Liu Y., Ostendorf B.N., Yamaguchi N., Arab A., Tavora B., Timson R., Heissel S., de Stanchina E., Molina H., Victora G.D., Goodarzi H., Birsoy K.*. Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells. Cell Metabolism 33(1): 211–221, 2021.

1. Soula M., Weber R.A., Zilka O., Alwaseem H., La K., Yen F., Molina H., Garcia-Bermudez J., Pratt D.A., and Birsoy K.*. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inhibitors. Nature Chemical Biology. 16(12): 1351–1360, 2020.
2. Bayraktar E.C., La K., Karpman K., Unlu G., Ozerdem C., Ritter D.J., Alwaseem H., Molina H., Hoffmann H.H., Millner A., Atilla-Gokcumen G.E., Gamazon E.R., Rushing A.R., Knapik E.W., Basu S., and Birsoy K.*. Metabolic co-essentiality mapping identifies c12orf49 as a regulator of SREBP processing and cholesterol metabolism. Nature Metabolism. 2(6): 487–498, 2020.
3. Williams R.T., Guarecuco R., Gates L.A., Barrows D., Passarelli M.C., Carey B., Baudrier L., Jeewajee S., La K., Prizer B., Malik S., Garcia-Bermudez J., Zhu X., Cantor J., Molina H., Carroll T., Roeder R.G., Abdel-Wahab O., Allis C.D., and Birsoy K.*. ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metabolism. 31(4): 852–861, 2020.
4. Weber R.A., Yen F.S., Nicholson S.P.V., Alwaseem H., Bayraktar E.C., Alan M., Timson R.C., La K., Abu Remalieh M., Molina H., and Birsoy K.*. Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation. Molecular Cell. 77(3): 645–655, 2020.

1. Zhu X.G., Nicholson Puthenveedu P., Shen Y., La K., Ozlu C., Wang T., Klompstra D., Gultekin Y., Chi J., Fidelin J., Peng T., Molina H., Hang H.C., Min W., and Birsoy K.*. CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Molecular Cell. 74(1): 45–58, 2019.
2. Garcia-Bermudez J., Baudrier L., Bayraktar E.C., Shen Y., La K., Guarecuco R., Yucel B., Fiore D., Tavora B., Freinkman E., Chan S.H., Lewis C., Min W., Inghirami G., Sabatini D.M., and Birsoy K.*. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 567(7746): 118–122, 2019.

1. Garcia-Bermudez J., Baudrier L., La K., Zhu X.G., Fidelin J., Sviderskiy V.O., Papagiannakopoulos T., Molina H., Snuderl M., Lewis C.A., Possemato R.L., and Birsoy K.*. Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. 20(7): 775–781, 2018.