2022
Kenny K, Khan A, Son Y, Heissel S, Alwaseem H, Hite R and Birsoy K. Integrative genetic analysis identified FLVCR1 as an essential component of choline transport in mammals. https://doi.org/10.1101/2022.10.05.509986. bioRxiv. 2022.
Unlu G, Prizer B, Erdal R, Yeh HW, Bayraktar EC, Birsoy K. Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Mol Cell. 2022 Aug 4;82(15):2832-2843.e7. doi: 10.1016/j.molcel.2022.05.024. Epub 2022 Jun 16. PMID: 35714613
Garcia-Bermudez J., Prasad S., Baudrier L., Badgley M.A., Liu Y., La K., Soula M., Williams R.T., Yamaguchi N., Hwang R.F., Taylor L.J., De Stanchina E., Rostandy B., Alwaseem H., Molina H., Bar-Sagi D*., Birsoy K.* (2021). Adaptive stimulation of micropinocytosis overcomes aspartate limitation in cancer cells under hypoxia. Nat Metab. 2022 Jun;4(6):724-738. doi: 10.1038/s42255-022-00583-z. Epub 2022 Jun 20.
PMID: 35726024
2021
Wang Y., Yen F., Zhu X.G., Timson R.C., Weber R., Xing C., Liu Y., Allwein B., Luo H., Yeh H.W., Heissel S., Unlu G., Gamazon E.R., Kharas M.G., Hite R. and Birsoy K.* (2021) SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature. 2021 Nov;599(7883):136-140. doi: 10.1038/s41586-021-04025-w. Epub 2021 Oct 27. PMID: 34707288
Garcia-Bermudez J. and Birsoy K.* (2021). A mitochondrial gatekeeper that helps cells escape death by ferroptosis. Nature 593: 514-515.
Zhu X.G., Chudnovskiy A., Baudrier L., Prizer B., Liu Y., Ostendorf B.N., Yamaguchi N., Arab A., Tavora B., Timson R., Heissel S., de Stanchina E., Molina H., Victora G.D., Goodarzi H., Birsoy K.* (2021) Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells. Cell Metab 33(1): 211-221.
2020
Guarecuco R., Williams R.T., Baudrier L., La K, Passarelli M.C., Ekizoglu N., Mestanoglu M., Alwaseem H., Rostandy B., Fidelin J., Garcia-Bermudez J., Molina H, Birsoy K.* (2020). Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells. Science Advances. 6(41).
Soula M., Weber R.A., Zilka O., Alwaseem H., La K., Yen F., Molina H., Garcia-Bermudez J., Pratt D.A. and Birsoy K.* (2020) Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inhibitors. Nature Chemical Biology 16(12):1351-1360.
Parsa s., Ortega-Molina A., Ying H., Jiang M., Teater M., Wang J., Zhao C., Reznik E., Pasion J.P., Kuo D., Mohan P., Wang S., Camarillo J.M., Thomas P.M., Jain N., Garcia-Bermudez J., Cho B., Tam W., Kelleher N.L., Socci N., Dogan A., De Stanchina E., Ciriello G., Green M.R., Li S., Birsoy K., Melnick A.M., Wendel H.G. (2020) The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nature Cancer 1(6): 653-664.
Bayraktar E. C., La K., Karpman K., Unlu G., Ozerdem C., Ritter D. J., Alwaseem H., Molina H., Hoffmann H. H., Millner A., Atilla-Gokcumen G. E., Gamazon E. R., Rushing A. R., Knapik E. W., Basu S. and Birsoy K.* (2020). Metabolic co-essentiality mapping identifies c12orf49 as a regulator of SREBP processing and
cholesterol metabolism. Nature Metab 2(6): 487-498.
Hedbacker K., Lu Y., Dallner O., Li Z., Fayzikhodjaeva G., Birsoy K., Han C., Yang C., Friedman J.M. (2020) Limitation of adipose tissue by the number of embryonic progenitor cells. eLife 9: e53074
Surface L.E., Burrow D.T., Li J., Park J., Kumar S., Lyu C., Song N., Yu Z., Rajagopal A., Bae Y., Lee B.H., Mumm S., Gu C.C., Baker J.C., Mohseni M., Sum M., Huskey M., Duan S., Bijanki V.N., Civitelli R., Gardner M.J., McAndrew C.M., Ricci W.M., Gurnett C.A., Diemer K., Wan F., Costantino C.L., Shannon K.M., Raje N., Dodson T.B., Haber D.A., Carette J.E., Varadarajan M., Brummelkamp T.R., Birsoy K., Sabatini D.M., Haller G., Peterson T.R.. (2020) ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Science Transl. Medicine 12(544).
Williams R. T., Guarecuco, R., Gates L. A., Barrows D., Passarelli M. C., Carey B., Baudrier L., Jeewajee S., La K., Prizer B., Malik S., Garcia-Bermudez J., Zhu X., Cantor J., Molina H., Carroll T., Roeder R. G., Abdel-Wahab O., Allis C. D. and Birsoy K.*. (2020). ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metab 31(4): 852-861.
Weber R. A., Yen F. S., Nicholson S. P. V., Alwaseem H., Bayraktar E. C., Alan M., Timson R. C., La K., Abu Remalieh M., Molina H. and Birsoy K.*. (2020). Maintaining iron homeostasis is the key role of lysosomal acidity for cell proliferation. Mol Cell 77(3): 645-655.
Garcia-Bermudez J., Williams R. T., Guarecuco R., Birsoy K.* (2020). Targeting extracellular nutrient dependencies of cancer cells.Mol Metab 33: 67-82.
Liberti M. and Birsoy K.* (2020). A link between metabolic energetics and pancreatic cancer mechanosensing. Nature Metab 2: 5-6.
2019
Weber R. and Birsoy K.* (2019). The Transsulfuration Pathway Makes, the Tumor Takes. Cell Metab 30(5): 845-846.
Zhu X. G. and Birsoy K.* Deciphering cellular heterogeneity of pancreatic tumours. Nat Cell Biol (2019). 21(11): 1305-1306.
Phillips R. E., Yang Y., Smith R. C., Thompson B. M., Yamasaki T., Soto-Feliciano Y. M., Funato K., Liang, Y. Garcia-Bermudez J., Wang X., Garcia B. A., Yamasaki K., McDonald J. G., Birsoy K., Tabar V. and Allis C. D. (2019). Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc Natl Acad Sci U S A 116(16): 7957-7962.
Birsoy K. and Sancak Y. (2019). The role of metabolism in cellular processes. Mol Biol Cell 30(6): 733.
Zhu X. G., Nicholson Puthenveedu P., Shen Y., La K., Ozlu C., Wang T., Klompstra D., Gultekin Y., Chi J., Fidelin J., Peng T., Molina H., Hang H. C., Min W. and Birsoy K.* (2019). CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Mol Cell 74(1): 45-58.
Garcia-Bermudez J., Baudrier L., Bayraktar E. C., Shen Y., La K., Guarecuco R., Yucel B., Fiore D., Tavora B., Freinkman E., Chan S. H., Lewis C., Min W., Inghirami G., Sabatini D. M. and Birsoy K.* (2019). Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature 567(7746): 118-122.
Dallner O. S., Marinis J. M., Lu Y. H., Birsoy K., Werner E., Fayzikhodjaeva G., Dill B. D., Molina H., Moscati A., Kutalik Z., Marques-Vidal P., Kilpelainen T. O., Grarup N., Linneberg A., Zhang Y., Vaughan R., Loos R. J. F., Lazar M. A. and Friedman J. M. (2019). Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nat Med 25(3): 507-516.
Bayraktar E. C., Baudrier L., Ozerdem C., Lewis C. A., Chan S. H., Kunchok T., Abu-Remaileh M., Cangelosi A. L., Sabatini D. M., Birsoy K.* and Chen W. W. (2019). MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proc Natl Acad Sci U S A 116(1): 303-312.
2018
Zhang M., Di Martino J. S., Bowman R. L., Campbell N. R., Baksh S. C., Simon-Vermot T., Kim I. S., Haldeman P., Mondal C., Yong-Gonzales V., Abu-Akeel M., Merghoub T., Jones D. R., Zhu X. G., Arora A., Ariyan C. E., Birsoy K., Wolchok J. D., Panageas K. S., Hollmann T., Bravo-Cordero J. J. and White R. M. (2018). Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins. Cancer Discov 8(8): 1006-1025.
Peng X., Chen Z., Farshidfar F., Xu X., Lorenzi P. L., Wang Y., Cheng F., Tan L., Mojumdar K., Du D., Ge Z., Li J., Thomas G. V., Birsoy K., Liu L., Zhang H., Zhao Z., Marchand C., Weinstein J. N.,Cancer Genome Atlas Research, Bathe O. F. and Liang H. (2018). Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Cell Rep 23(1): 255-269 e254.
Minton D. R., Nam M., McLaughlin D. J., Shin J., Bayraktar E. C., Alvarez S. W., Sviderskiy V. O., Papagiannakopoulos T., Sabatini D. M., Birsoy K.* and Possemato R*. (2018). Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Mol Cell 69(4): 610-621 e615.
Garcia-Bermudez J., Baudrier L., La K., Zhu X. G., Fidelin J., Sviderskiy V. O., Papagiannakopoulos T., Molina H., Snuderl M., Lewis C. A., Possemato R. L. and Birsoy K.* (2018). Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nat Cell Biol 20(7): 775-781.
Dubard Gault M., Mandelker D., DeLair D., Stewart C. R., Kemel Y., Sheehan M. R., Siegel B., Kennedy J., Marcell V., Arnold A., Al-Ahmadie H., Modak S., Robson M., Shukla N., Roberts S., Vijai J., Topka S., Kentsis A., Cadoo K., Carlo M., Latham Schwark A., Reznik E., Dinatale R., Hechtman J., Borras Flores E., Jairam S., Yang C., Li Y., Bayraktar E. C., Ceyhan-Birsoy O., Zhang L., Kohlman W., Schiffman J., Stadler Z., Birsoy K., Kung A., Offit K. and Walsh M. F. (2018). Germline SDHA mutations in children and adults with cancer. Cold Spring Harb Mol Case Stud 4(4).
2017
Secco B., Camire E., Briere M. A., Caron A., Billong A., Gelinas Y., Lemay A. M., Tharp K. M., Lee P. L., S. Gobeil, Guimond J. V., Patey N., Guertin D. A., Stahl A., Haddad E., Marsolais D., Bosse Y., Birsoy K. and Laplante M. (2017). Amplification of Adipogenic Commitment by VSTM2A. Cell Rep 18(1): 93-106.
Reczek, C. R., Birsoy K., Kong H., Martinez-Reyes I., Wang T., Gao P., Sabatini D. M. and Chandel N. S. (2017). A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nat Chem Biol 13(12): 1274-1279.
Ilic N., Birsoy K., Aguirre A. J., Kory N., Pacold M. E., Singh S., Moody S. E., DeAngelo J. D., Spardy N. A., Freinkman E., Weir B. A., Tsherniak A., Cowley G. S., Root D. E., Asara J. M., Vazquez F., Widlund H. R., Sabatini D. M. and Hahn W. C. (2017). PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proc Natl Acad Sci U S A 114(17): E3434-E3443.
Alvarez S. W., Sviderskiy V. O., Terzi E. M., Papagiannakopoulos T., Moreira A. L., Adams S., Sabatini D. M.*, Birsoy K.* and Possemato R.* (2017). NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature 551(7682): 639-643.
2016
Pacold M. E., Brimacombe K. R., Chan S. H., Rohde J. M., Lewis C. A., Swier L. J., Possemato R., Chen W. W., Sullivan L. B., Fiske B. P., Cho S., Freinkman E., Birsoy K., Abu-Remaileh M., Shaul Y. D., Liu C. M., Zhou M., Koh M. J., Chung H., Davidson S. M., Luengo A., Wang A. Q., Xu X., Yasgar, Liu L., Rai G., Westover K. D., Vander Heiden M. G., Shen M., Gray N. S., Boxer M. B. and Sabatini D. M. (2016). A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol 12(6): 452-458.
Garcia-Bermudez J. and Birsoy K.* (2016). Drugging ACAT1 for Cancer Therapy. Mol Cell 64(5): 856-857.
Chidley C., Trauger S. A., Birsoy K. and O'Shea E. K. (2016). The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine. Elife 5.
